Director, Program Management

Landmark Bio is dedicated to translating cutting-edge research into life-changing therapies. Headquartered in Watertown, Massachusetts, the company was founded by leading academic institutions, research hospitals, and industry partners to accelerate the development, manufacturing, and commercialization of advanced therapies. Driven by the compelling science and transformative potential of genetic medicine, Landmark Bio offers deep drug development expertise and integrated end-to-end solutions to support its partners. The company also serves as a collaborative platform to advance next-generation manufacturing technologies for novel modalities. Following its acquisition by Artis BioSolutions in 2025, Landmark Bio continues to operate as a distinct entity.  Learn more at www.landmarkbio.com. 

We are seeking a highly motivated and team-oriented professional with entrepreneurial spirit to join our company! This is an exciting opportunity for a well-qualified candidate to join a rapidly growing company focused on turning today’s cutting-edge research into tomorrow’s breakthrough therapies.

The Director of Program Management will lead the execution of complex, cross-functional client programs focused on the development and GMP manufacturing of cell and gene therapies. This role is responsible for ensuring program success across a diverse client base—including academic institutions, biotech companies, and government agencies—while managing a high-performing team of Program Managers and driving alignment with strategic and operational objectives.

This role requires deep understanding of GMP operations, program and stakeholder management, and the ability to lead both internal teams and external clients with clarity, confidence, and accountability. 

Scope of Responsibilities:

·       Lead and oversee multiple complex, cross-functional client programs from contract award through closure, ensuring on-time, on-budget, and on-scope delivery. 

·       Manage and develop a team of Program Managers and Coordinators, fostering a culture of ownership, client service excellence, and continuous improvement. 

·       Own the client relationship for assigned programs; serve as the main point of contact and ensure program health, transparency, and trust with both internal and external stakeholders. 

·       Develop and maintain program documentation, including charters, timelines, risk registers, change orders, budgets, meeting minutes, and stakeholder reports. 

·       Drive strategic alignment between program objectives and broader business goals; contribute to long-term planning, client development, and organizational strategy. 

·       Collaborate cross-functionally with Process & Analytical Development, Quality, GMP Manufacturing, Supply Chain, Facilities, and Regulatory to deliver program milestones. 

·       Identify and manage program risks through proactive mitigation planning and structured risk management frameworks. 

·       Track and report on key performance indicators (KPIs), such as delivery timelines, client satisfaction, quality metrics, and budget adherence. 

·       Lead program steering committees and governance forums; prepare executive-level presentations and reports for internal and client leadership. 

·       Contribute to the development of scalable PMO tools and frameworks, including Smartsheet dashboards, process maps, and templates. 

·       Oversee programs funded through government contracts or academic grants, ensuring compliance with sponsor guidelines, milestones, and reporting requirements. 

·       Champion process improvements, lead root-cause analyses for program deviations, and contribute to organizational learning and maturity. 

Qualifications:

·       BA/BS degree in a relevant field required; advanced degree (MS, MBA, PhD) is a plus. 

·       10+ years of program or project management experience in life sciences, with at least 5 years leading cross-functional programs in GMP manufacturing of cell, gene, or biologic therapies. 

·       3+ years of people management experience, including direct reports and matrixed team leadership. 

·       Demonstrated experience managing grant-funded or government-supported programs (e.g., NIH, BARDA, ARPA-H, academic collaborations). 

·       Proven ability to lead client-facing engagements, manage complex stakeholders, and resolve cross-functional conflicts. 

·       PMP certification or equivalent is preferred. 

·       Strong knowledge of project management tools and systems, including Smartsheet, Microsoft Project, and PowerPoint. 

·       Deep understanding of GMP principles and regulated development environments. 

·       Demonstrated financial acumen, including budget tracking and change order management. 

·       Experience working in a matrixed, fast-paced, and early-stage environment is a plus. 

This role is hybrid and will require onsite support for client engagements and cross-functional meetings.  The candidate will need to be located in the Watertown, MA area or able to commute up to several days per week as required. 

Landmark Bio is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans, and individuals with disabilities are encouraged to apply.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law may be subject to criminal penalties and civil liability.