Senior Director, Health Economics and Outcomes Research (HEOR) - job 2 of 2

This position is posted by Jobgether on behalf of Axsome Therapeutics. We are currently looking for a Senior Director, Health Economics and Outcomes Research (HEOR) in New York (USA).

This senior leadership role offers the opportunity to shape and drive the strategic vision for health economics and outcomes research across the product lifecycle. You will lead efforts to generate compelling real-world evidence and economic data that support market access, reimbursement, and stakeholder engagement. Working at the intersection of clinical development, commercial, and medical affairs teams, you will influence decision-making and ensure that products demonstrate meaningful value to patients, payers, and healthcare providers. The role demands a collaborative, innovative leader comfortable in a fast-paced, matrixed environment.

Accountabilities:

• Develop and execute HEOR strategies and evidence generation plans in collaboration with cross-functional teams to address clinical and payer needs.
• Lead observational research, economic modeling, patient-reported outcomes studies, and real-world evidence initiatives to support value propositions.
• Collaborate closely with Medical Affairs, Market Access, Commercial, and external partners to optimize evidence dissemination and product positioning.
• Manage internal and external stakeholder expectations while overseeing study design, protocol development, budget management, and timelines.
• Provide expert input on HEOR endpoints in clinical trials and contribute to health economic dossier development for global markets.
• Represent the organization at scientific meetings, advisory boards, and in interactions with thought leaders and payers.
• Ensure compliance with corporate policies and relevant healthcare laws and regulations.

• Advanced degree (MSc, MPH, PhD, PharmD, MD) in health economics, epidemiology, health outcomes research, or related field.
• Minimum 10 years of pharmaceutical or life sciences HEOR experience, preferably with neuroscience exposure.
• Proven expertise in real-world evidence study design, execution, and communication.
• Deep understanding of observational research methods, regulatory standards, and health economic modeling techniques.
• Experience with clinical datasets including EHRs, claims, registries, and patient-reported data.
• Strong leadership, communication, interpersonal, and project management skills.
• Ability to influence senior leaders and work effectively in a matrixed, fast-paced environment.
• On-site presence required at least three days per week in New York; remote-only candidates will not be considered.
• Experience in reimbursement and market access environments and budget management.
• Strategic mindset with attention to detail and ability to manage multiple priorities.

• Competitive salary range of $250,000 - $275,000 USD, with flexibility based on experience and qualifications.
• Annual bonus and significant equity participation.
• Comprehensive benefits package including health insurance, retirement plans, and paid time off.
• Opportunity for career growth within an innovative biopharmaceutical company.
• Inclusive and supportive work environment committed to diversity and equal opportunity.

Jobgether is a Talent Matching Platform that partners with companies worldwide to efficiently connect top talent with the right opportunities through AI-driven job matching.

When you apply, your profile goes through our AI-powered screening process designed to identify top talent efficiently and fairly.
🔍 Our AI evaluates your CV and LinkedIn profile thoroughly, analyzing your skills, experience, and achievements.
📊 It compares your profile to the job’s core requirements and past success factors to determine your match score.
🎯 Based on this analysis, we automatically shortlist the 3 candidates with the highest match to the role.
🧠 When necessary, our human team may perform an additional manual review to ensure no strong profile is missed.

The process is transparent, skills-based, and free of bias — focusing solely on your fit for the role. Once the shortlist is completed, we share it directly with the company that owns the job opening. The final decision and next steps (such as interviews or additional assessments) are then made by their internal hiring team.

Thank you for your interest!

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